Sunday 26 June 2016

organic chemistry - Does acetamide respond positively to iodoform test?


This answer explains why acetic acid does not give a positive iodoform test.



Does acetamide respond positively to the test?



Answer



From wikipedia article of haloform reaction:



Acetyl chloride and acetamide don't give this (iodoform or in general haloform) test.



Why?



Acetamide is not a ketone which is substantially more acidic than the amide.  It's about a million times too weak an acid at the alpha protons. Hydroxide is too weak a base. (Quora)




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